Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors

We managed perioperative hemostasis for a 72-year-old man with hemophilia A and low inhibitor titers (3 BU/mL), who underwent osteosynthesis for supracondylar fracture of the left humerus.He was treated perioperatively using the combination of high doses of factor VIII (FVIII) bauhaus stencil with recombinant human Factor VIII Fc fusion protein (rF

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Disitamab vedotin combined with pyrotinib as salvage treatment in Her-2-amplified treatment refractory metastatic colorectal cancer: a case report

BackgroundHuman epidermal growth factor receptor 2 (HER-2) amplification has been identified in approximately 3% of patients with metastatic colorectal u motion bowling ball cancer (mCRC).Owing to the lack of established anti-ERBB2 therapeutic approaches, mCRC patients with Her-2 amplification rarely receive targeted treatments.Moreover, convention

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The complete mitochondrial genome sequence of the edible mushroom Stropharia rugosoannulata (Strophariaceae, Basidiomycota)

Stropharia rugosoannulata (Strophariaceae, Basidiomycota) is an edible mushroom distributed in northern temperate zones throughout the world.In this study, the complete mitochondrial genome sequence of S.rugosoannulata was determined.This mitochondrial genome is 60,551 bp in length with a GC content of 31.0% and encodes 14 tommy todd ointment conse

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